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        胃溃疡硕士毕业论文 多药联合治疗小儿活动性胃溃疡的效果观察

        版权:原创标记本站原创 星级:★★★★4.0主题:胃溃疡1500字范文 级别:完整学术论文 范畴:专科学术论文 论文范文编号:biyelunwendq0323511 期刊发表:初级职称 全文字数:8000字 投稿作者:pgtaph 审稿编辑:专家学者 阅读次数:31798

        本论文是一篇免费优秀的关于胃溃疡论文范文资料,可用于相关论文写作参考。

        多药联合治疗小儿活动性胃溃疡的效果观察[摘要] 目的 观察多药联合治疗小儿活动性胃溃疡(GU)的效果及对幽门螺杆菌(Hp)根除率的影响。 策略 选取徐州市儿童医院2012年8月~2013年8月收治的活动性GU患儿104例,随机分为观察组及对照组,每组各52例。对照组给予三联疗法方式治疗,观察组在对照组基础上,联合给予益生菌治疗。对比两组患儿治疗效果、Hp根除情况及不良反应发生情况。 结果 观察组治疗总有效率显著高于对照组,观察组Hp根除率显著高于对照组,恶心呕吐及腹胀不良反应发生率显著低于对照组,差异均有统计学作用(P < 0.05)。 结论 多药联合治疗小儿活动性GU,可有效提高治疗效果,提升Hp根除率,并降低不良反应发生率。

        胃溃疡1500字论文 胃溃疡1500字

        雷贝拉唑联合瑞巴派特治疗活动性胃溃疡的疗效

        雷贝拉唑联合磷酸铝凝胶治疗幽门螺旋杆菌阳性胃溃疡的疗效

        西黄胶囊结合盐酸 缓释片治疗中晚期肺癌疼痛临床效果观察

        熏洗方治疗肛瘘术后创面肿痛的临床观察

        [关键词] 多药联合;小儿活动性胃溃疡;疗效

        [] A [文章编号] 1673-7210(2014)09(b)-0058-04

        胃溃疡(Gastric ulcer,GU)作为一种较为常见的慢性全身病症,主要可分成胃溃疡及十二指肠溃疡。此病多因胃酸及胃蛋白酶对于胃黏膜的长期侵袭以及自身消化而产生,与其他因素合并后即可形成溃疡病。过去一直认为胃酸分泌量过多为主要致病因素,应用制酸剂或者抑酸剂进行治疗,仅可以短时间制约病情,复发率极高,难以治愈[1]。GU及十二指肠溃疡的病因及临床症状存在较多相似之处,常难以区分?;颊咛弁床课灰渤4υ诮M幌?,亦或是上腹部的中线四周,表现为灼烧性和饥饿性钝痛,以及胀、隐痛等较多临床症状。近年来,经过国内外医学工作者仔细研究[2],发现幽门螺杆菌(Helicobacter pylori,Hp)与GU发病联系密切。因此,对GU治疗方向确定为抗酸和抗菌同时进行。临床上对于小儿活动性GU治疗,通常选用三联疗法,即具有抗酸、抗Hp功能3种药物搭配共用。运用三联疗法治疗虽取得一定治疗效果,但是总有效率及Hp根除率不尽满意,且用药后不良反应较重,加重患儿痛苦。有专家提出,通过联合应用益生菌治疗,可提高疗效,并能够减轻不良反应发生[3]。本文通过研究多药联合治疗小儿活动性GU的效果及其对Hp根除率的影响,得到相关结论,现报道如下:

        1 资料与策略

        1.1 一般资料

        选取徐州市儿童医院(以下简称“我院”)2012年8月~2013年8月收治的活动性GU患儿104例,均经13C-尿素呼气试验(13C-UBT)测定结果为13C-UBT阳性,均有反复发作的上腹痛或脐周腹痛,且疼痛并无规律,疼痛时间2~24个月;腹痛但不伴有呕吐及腹泻,且B超诊断无异常,就诊检查前亦无服药史。其中男54例,女50例;年龄3~13岁,平均年龄(8.3±1.2)岁。纳入标准:无Hp根除治疗史;近4周未接受抗生素、H2及PPI受体阻断剂等治疗;无相关药物过敏史;无因溃疡导致脏器损害或并发症。以数字计数法随机分成观察组及对照组,每组各52例。其中观察组男28例,女24例;年龄3~12岁,平均年龄(8.0±1.1)岁。对照组男26例,女26例;年龄4~13岁,平均年龄(8.5±1.3)岁。两组患儿在性别、年龄及症状等一般资料比较,差异无统计学作用(P > 0.05),具有可比性。

        常见流行病 胃溃疡简介

        时事政治的论文高中政治教研论文思想政治硕士论文高中政治论文2000字思想政治论文参考文献中学生政治小论文

        1.2 治疗策略

        对照组给予三联疗法方式治疗:奥美拉唑肠溶胶囊0.9 mg/(kg·d)(北京韩美药品有限公司,国家准字H20060390),阿莫西林30 mg/(kg·d)(福州海王福药,闵卫准字000111)、克拉霉素15 mg/(kg·d)(江苏恒瑞药业,国家准字H20031041);观察组在对照组基础上,联合给予复方嗜酸乳杆菌片500 mg(通化金马药业,国家准字H10940114)。两组均连续用药1周。

        多药联合治疗小儿活动性胃溃疡的效果观察大学毕业论文范文相关参考属性
        有关论文范文主题研究: 胃溃疡相关论文范文 大学生适用: 3000字学院论文
        相关参考文献下载数量: 49 写作解决问题: 学术论文怎么写
        毕业论文开题报告: 标准论文格式、论文选题 职称论文适用: 期刊目录、高级职称
        所属大学生专业类别: 胃溃疡1500字科目 论文题目推荐度: 最新胃溃疡题目

        1.3 观察指标及疗效判定

        停药之后4周进行复查,检测13C-UBT,并询问用药后效果。对比两组患儿治疗效果、Hp根除情况及不良反应发生情况。

        疗效判定[4]:临床症状完全消失为显效;临床症状基本消失,发生频率较小且持续时间短为有效;仍然时常伴有临床症状,但发生频率减少且持续时间缩短为好转;临床症状无减轻或加重为无效。总有效率=[(显效+有效+好转)/总例数]×100%。HP根除判定:停药之后4周做13C-UBT,结果为阴性者为根除[5]。

        1.4 统计学策略

        采用SPSS 13.0对数据进行分析,正态分布计量资料以均数±标准差(x±s)表示,两组间比较采用t检验;计数资料以率表示,采用χ2检验。以P < 0.05为差异有统计学意义。

        2 结果

        2.1 两组患儿治疗效果

        观察组治疗总有效率显著高于对照组,差异有统计学作用(P < 0.05)。见表1。

        2.2 两组患儿Hp根除率

        观察组Hp根除率显著高于对照组,差异有统计学作用(P < 0.05)。见表2。

        2.3两组患儿治疗后不良反应发生情况

        观察组治疗后不良反应发生率均低于对照组,特别是恶心呕吐及腹胀发生率显著低于对照组,差异有统计学作用(P < 0.05)。见表3。

        3 讨论

        胃是人体的一种重要消化器官,解剖学发现,人类胃壁表层含有一层较薄的胃黏膜,主要分成上皮层、固有层及黏膜肌层。若受外来因素

        2

        参考文献:

        [1]多药联合治疗小儿活动性胃溃疡的效果观察

        [2]多药联合治疗小儿活动性胃溃疡的效果观察

        权威评价

        胃溃疡本科论文初稿怎么写?本论文为您写常见流行病 胃溃疡简介毕业论文范文和职称论文提供相关论文参考文献,可免费下载,适合对照组和活动性和患儿论文写作的大学硕士及关于胃溃疡1500字本科毕业论文参考.

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